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|Titolo:||Toxicity of exposure to binary mixtures of four anti-neoplastic drugsin Daphnia magna and Ceriodaphnia dubia|
|Autori interni:||ISIDORI, Marina|
|Data di pubblicazione:||2014|
|Abstract:||tAnticancer drugs, interfering with DNA in every living organism, may pose a threat to aquatic environ-ment, even more when they occur as complex mixtures. We investigated the combined long term toxicpotential of four anti-neoplastic drugs (5-fluorouracil [5-FU], cisplatin [CDDP], etoposide [ET] and imat-inib mesylate [IM]) testing their binary mixtures on two primary consumers of the freshwater aquaticchain with close phylogenetic relationship: Daphnia magna and Ceriodaphnia dubia. The combined toxi-cities were assessed using two distinct effect sizes that should be observed if Bliss independence holds.Direct statistical comparison by analysis of variance of single and combined toxicities under the assump-tion of Bliss independence allowed to accept or reject the independency hypothesis. Independency wasconfirmed for all mixtures both in D. magna and in C. dubia, except for IM+ ET and IM + CDDP in D. magnaand for ET + CDDP and ET + 5-FU in C. dubia which at the highest concentrations showed an antagonisticinteraction. A synergic tendency was found testing IM + CDDP on C. dubia at the lowest concentrationselected. Thus, the chronic ecotoxicological data evaluated in this study show not only a potential envi-ronmental risk of anticancer drugs, especially considering their potential synergistic effects, but alsothe necessity to integrate statistical models with experimental data to establish the real environmentalimpact of such compounds.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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